Metformin - Glucophage

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Metformin - Glucophage

I have been interested in the use of metformin for sometime. Metformin has been shown to inhibit cell growth so for someone who is at a higher risk of cancer the benefit is obvious. On the flip side those who are looking to gain as much muscle as possible this could be seen as a negative. The ability of metformin to dispose of glucose will make it an interesting consideration for individuals who are wanting to maximize the effects of a keto diet or are carb sensitive.

Some of the effects of metformin for bodybuilders will have an impact on muscle growth... inhibition of cell growth, reduces IGF-1 receptor sensitivity, etc. 

I recently added a low dose of metfromin to my cutting cycle of Test/Tren/Primo. I am currently in ketosis. I started dosing approx. 200mg (1/4 825mg tab) of metforin with two carb meals a day. My carbs were limited to 35 carbs per meal. As of yesterday I have changed the strategy. I have a 35g carb meal post am workout and no metformin. My early evening meal contains 35g carbs and 200mg metformin. Late evening meal is 50g protein only. The goal is to dispose of the glucose of the early evening meal while sleeping allowing me to immediately achieve ketosis upon waking and begin utilizing fatty acids (fat) for energy for my am training session. I have not experienced any of the gastric side effects of the drug because of the low dosage. I will up the dosage if needed based on first am ketosis urine test strip.

My personal feeling is that metformin has limited use in a pure cutting cycle. I am simply experimenting with it for personal reasons and under supervision. For those who are looking to build mass metformin should not even be a consideration . I would have to say it is useless to include it in a bulking cycle not only because of the negative impacts on cell growth but it will also reduce hunger..... not good. ;) 

Here is a short video on an explanation of metformin (glucophage). Matt is a pretty no nonsense guy.....

 

Here is a research paper on AMPK that Matt discusses in the video -

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779044/

 

 SEMPER FI

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Thanks SF, good info +1

Thanks SF, good info +1

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Great post SF! I'm getying

Great post SF! I'm getying beefy right now, so definitely none for me.

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SF

Don't stop reading my mind! Every substance I am looking at lately, you are posting great info on!!! I think you are psychic!!!

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Just feeling the vibe of the

Just feeling the vibe of the community! ;)

We get to know each other pretty well after a short time..... that is why I couldn't leave.

 

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Thank you

For returning to us.

Thank you for everything that makes you who you are! 

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X2 Calm...  SemperFi is a

X2 Calm...  SemperFi is a deep thinker. I'm glad he thought to take a look at his actions and stew on them for a while and change his mind and thought pattern. This is what being an adult, leader and an all around humble person is all about...

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SF is a great guy and

SF is a great guy and valuable to the community. He's the guy who will try and change what he can't change, but trys because he's willing to stand up for what he believes is right. That's just that Marine Corp frontal assault maneuver. In the Army we liked to use a flanking assault. Make you think were coming at you here, but really hit you there. Lol

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Yes indeed

Strong! 

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I think he may be psychic

I think he may be psychic (psycho at times). I was thinking of using a different GDA, and out of fucking nowhere SF is all like if youre thinking of using that, dont. More or less anyways :)

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UPDATE-

UPDATE-

I am able to stay in ketosis upon waking but the test strip is pink in color and not the strong magenta that I like to see. I will have to make a decision to either reduce the early evening carbs or increase the metformin. The problem with increasing the dosage without increasing the carbs I will probably go hypo. I think what I am going to do is increase carbs to 50g and increase the metformin to 425mg. I will run this for a few days and make small tweaks to the carbs until I find the magenta color on the test strip upon waking. If that does not work I may have to go back to the original dosage and reduce the carbs.

I have seen a slight benefit to muscle uptake of glucose. I mean it isn't anything obvious to an onlooker. I notice more muscle fullness shortly after taking metfromin. Like I said it isn't anything major but it is enough that I have been taking notice.

 

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UPDATE-

UPDATE-

50g carbs and 425mg metformin- no ketosis test strip change. I will taper carbs down to 40g tonight.

 

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UPDATE-

UPDATE-

40g and 425mg provided a darker test strip. This will be my basis for the next six week. I began a deficit as of today and the goal is to reach 4-5% BF. This is the most serious cut I have ever undertaken. My current weight is 222 and I am shooting for 205. 

My priority is to make weight, walk in full, maintain symmetry and still be leaner than all the pups in the room. That's not asking too much of myself is it? lol

I will have my personal final conclusion of metformin once I complete my prep.

 

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You got this SF. No problem.

You got this SF. No problem. Love the updates as this may influence whether i decide to run metformin down the road

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Go get em brother...

Go get em brother...

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Lead

The way, Semper Fi, lead the way!!!!

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Berberine is a very good

Berberine is a very good alternative. If taking metformin id recommend some injectible b vitamins

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Thanks for the recommendation

Thanks for the recommendation of injectable vitamin b. My ND is on top of it. ;)

FYI to members- Metformin can lead to a vitamin b12 deficiency.

 

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Facts are hard to accept

Facts are hard to accept sometimes. I only measured in at 70 1/4" which puts me in the weight category of 200lbs. After speaking with my trainer and close confidants they advised me that MCP is wrong for me. I never thought I would hear this but they told me I carry too much lean mass and to make weight is going to be crazy stressful at a sacrifice of quite a bit of muscle mass. Bitter sweet! Scratching this off my bucket list and adding it to my fucket list.  I am going to miss the challenge and experience but everything always works out in the end. ;)

Revamping the next six weeks into a ultra clean bulk. I am still going to shave off some fat but I will dump my keto diet and revert to a carb cycling diet. I haven't decided on a surplus yet because I just got out of the meeting. 

I am going to focus on my personal training business and share my experience while putting some play money in my pocket.... might even make enough to cover the cost of my supplements.... lol.

I will share my metformin experience mid October or so.... See you guys next time at 230lbs!

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Gotta do what you gotta do!

Gotta do what you gotta do! 230 at your height = monster status!

 

 

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Thanks Amigo! 

Thanks Amigo!

Chick drummers do something for me. :)

 

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How about mens bodybuilding?

How about mens bodybuilding? Sounds like you could crush that at 200-210

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I could but I won't for

I could but I won't for personal reason Blast. IFBB and NPC need to wake up and see what they are doing to their athletes. Until they begin to be accountable for the direction the have forced the BB division to go I will spend all my efforts in support of the less popular divisions.

 

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You have one helluva miral

You have one helluva miral compass, SF. Love it :)

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Well Blast, That's why I love

Well Blast, That's why I love the guy. His Moral Compass..  I wish the mass would understand to do things that are RIGHT instead of what benefits THEM.

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Whats hard for many of to see

Whats hard for many of to see is that right action does benefit the individual. Its no easy task, and its pretty damn cool we have folks like  those we find here to keep the lamp lit. I was tripping out a little on how fortunate i am to have found a tight batch of people that mutually support one another without even met in real life. I have a suspicion that this a rare occurence on the internet. Shit, in real life to a large degree. Oops! Hikackin the thread with tangents again lol!

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You give me too much credit

You give me too much credit brother. I try very hard to tow the line that has been given me but I have just as many shortcomings as the next person.

 

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Transitioned from acetate and

Transitioned from acetate and propinate to ethanate. Appears to be seemless. 400 calorie surplus per day. Carb cycling. 825mg of metforming on high carb days and approx 400mg on low carb days. Muscle fullness through the day. Good training pumps. Zero gastric side effects.

 

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Leaning out like never before

Leaning out like never before. Vascularity is off the wall sick. I have been increasing calories slowly on an almost daily basis. Fats are below 30g per day. I am not gaining much in the way of strength but I am gaining scale weight slowly at the current surplus while remaining lean as hell.

I am sticking with the carb cycling and metformin plan. I will stay on cycle until the end of October.

I am uncertain what I can attribute to the metformin or the tren but whatever is going on I like it!

 

SEMPER FI

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Sounds

Like great things are going on! Simply outfuckingstanding!

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Things are certainly taking

Things are certainly taking shape and different from other cycles. The vascularity was a huge surprise because I am pretty vascular normally but this round I have smaller veins making an appearance and in places I would have never expected. An arm or shoulder workout makes me look sick.... to the point that individuals I normally train with or on the same schedule are stopping and asking what the heck.... are you ok? It's awesome! My wife says it's disgusting.... lol.

I won't reach 230 by cycle end. An additional 8lbs lean is just too much to expect.

I will continue with this experiment and decide what comes next.

 

SEMPER FI

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I bet

The vascularity is sexy! To me at least. Even though you won't reach the 8 pounds,  results are still phenomenal!

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I am breaking my body on a

I am breaking my body on a monthly basis now. 2017 has been the year of injuries for me. As of today I am done juicing and will reinvent a healthy lifestyle that creates longevity and satisfaction for me personally.i will remain on a basic TRT regimen and use GH & Glucophage for their anti-aging effects.What a friggin' awesome ride of growth and development... better things are coming!

 

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You doing the SF stack for

You doing the SF stack for TRT? Its a damn go one in my opinion and experience. What, btw, did you break this time? Keep kickin ass brother deep into the future :)

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For now I am just going to

For now I am just going to run test. Strong gave me the advice to leave my options open so for today it will be what it is.

I have a partial tear in my right rotator cuff. Thanks for looking out Blaster.

 

SEMPER FI

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Damn, that sucks. Whats the

Damn, that sucks. Whats the recoup looking like for that? Shoulders are tricky

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I knew the day was coming JD.

I knew the day was coming JD. I just wasn't willing to make the decision on my own. 51 and strong willed! ;) Life has a way of creating paths we wouldn't choose ourselves so I am headed into this with great optimism. I am always looking for a new opportunity and I will see this one through.

With a partial tear surgery is rarely recommended anymore so I am in PT for 8 weeks and then get re-evaluated. Gives me a great opportunity to get the ticker in shape and do some more leg development.

 

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I don't know if this would

I don't know if this would even be helpful, but with the injuries starting to add up, have you ever tried cryotherapy? I'm spoiled in that I have a badass hormone clinic for bloodwork and a cryo clinic both right down the road from the house. I treat myself to cryo once a month or maybe twice if I need it. It's not cheap, but it can really help with the connective tissue aches and blood flow to some of those sore muscles. I would do it more if I could afford it. Feels great on my screwed and bolted back

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Thanks for the information JD

Thanks for the information JD. I have read about it but I have never considered using it for myself. I will see if this type on treatment is available locally and if it would be beneficial.

 

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Hate to hear that brother, I

Hate to hear that brother, I wish those healing peptides were worth a shit.  Maybe some kind of prolotherapy like stem cell prolotherapy Rogan has mentioned a number of times https://www.youtube.com/watch?v=IRZdH3TuGFY

  I was just reading this, you might find it of interest  https://drjohnrusin.com/prevent-45-of-soft-tissue-injuries-with-accentuated-eccentric-training/

 

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Thank you Metalhead for the

Thank you Metalhead for the information. 

 

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repeated

repeated

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You’ll always be a Hard

You’ll always be a Hard Charging Devil Dog Harder than woodpecker lips :))