Metformin - Glucophage

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Metformin - Glucophage

I have been interested in the use of metformin for sometime. Metformin has been shown to inhibit cell growth so for someone who is at a higher risk of cancer the benefit is obvious. On the flip side those who are looking to gain as much muscle as possible this could be seen as a negative. The ability of metformin to dispose of glucose will make it an interesting consideration for individuals who are wanting to maximize the effects of a keto diet or are carb sensitive.

Some of the effects of metformin for bodybuilders will have an impact on muscle growth... inhibition of cell growth, reduces IGF-1 receptor sensitivity, etc. 

I recently added a low dose of metfromin to my cutting cycle of Test/Tren/Primo. I am currently in ketosis. I started dosing approx. 200mg (1/4 825mg tab) of metforin with two carb meals a day. My carbs were limited to 35 carbs per meal. As of yesterday I have changed the strategy. I have a 35g carb meal post am workout and no metformin. My early evening meal contains 35g carbs and 200mg metformin. Late evening meal is 50g protein only. The goal is to dispose of the glucose of the early evening meal while sleeping allowing me to immediately achieve ketosis upon waking and begin utilizing fatty acids (fat) for energy for my am training session. I have not experienced any of the gastric side effects of the drug because of the low dosage. I will up the dosage if needed based on first am ketosis urine test strip.

My personal feeling is that metformin has limited use in a pure cutting cycle. I am simply experimenting with it for personal reasons and under supervision. For those who are looking to build mass metformin should not even be a consideration . I would have to say it is useless to include it in a bulking cycle not only because of the negative impacts on cell growth but it will also reduce hunger..... not good. ;) 

Here is a short video on an explanation of metformin (glucophage). Matt is a pretty no nonsense guy.....

 

Here is a research paper on AMPK that Matt discusses in the video -

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779044/

 

 SEMPER FI

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Thanks SF, good info +1

Thanks SF, good info +1

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Great post SF! I'm getying

Great post SF! I'm getying beefy right now, so definitely none for me.

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SF

Don't stop reading my mind! Every substance I am looking at lately, you are posting great info on!!! I think you are psychic!!!

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Just feeling the vibe of the

Just feeling the vibe of the community! ;)

We get to know each other pretty well after a short time..... that is why I couldn't leave.

 

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Thank you

For returning to us.

Thank you for everything that makes you who you are! 

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X2 Calm...  SemperFi is a

X2 Calm...  SemperFi is a deep thinker. I'm glad he thought to take a look at his actions and stew on them for a while and change his mind and thought pattern. This is what being an adult, leader and an all around humble person is all about...

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SF is a great guy and

SF is a great guy and valuable to the community. He's the guy who will try and change what he can't change, but trys because he's willing to stand up for what he believes is right. That's just that Marine Corp frontal assault maneuver. In the Army we liked to use a flanking assault. Make you think were coming at you here, but really hit you there. Lol

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Yes indeed

Strong! 

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I think he may be psychic

I think he may be psychic (psycho at times). I was thinking of using a different GDA, and out of fucking nowhere SF is all like if youre thinking of using that, dont. More or less anyways :)

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UPDATE-

UPDATE-

I am able to stay in ketosis upon waking but the test strip is pink in color and not the strong magenta that I like to see. I will have to make a decision to either reduce the early evening carbs or increase the metformin. The problem with increasing the dosage without increasing the carbs I will probably go hypo. I think what I am going to do is increase carbs to 50g and increase the metformin to 425mg. I will run this for a few days and make small tweaks to the carbs until I find the magenta color on the test strip upon waking. If that does not work I may have to go back to the original dosage and reduce the carbs.

I have seen a slight benefit to muscle uptake of glucose. I mean it isn't anything obvious to an onlooker. I notice more muscle fullness shortly after taking metfromin. Like I said it isn't anything major but it is enough that I have been taking notice.

 

SEMPER FI